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Ritonavir pépite lopinavir/ritonavir greatly increase plasma concentrations of oxycodone in healthy human volunteers due to inhibition of CYP3A4 and CYP2D6.[59] Rifampicin greatly reduces plasma concentrations of oxycodone due to strong induction of CYP3A4.

This medicine contains oxycodone which is an opioid medicine. Repeated traditions of opioid painkillers can result in the drug being less patente (you become accustomed to it, known as tolerance).

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